42 NEURONS LTD

42 NEURONS LTD
Private Limited Company

(99 reviews)
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Company name:

42 NEURONS LTD

Company Number:

11900553

Registered office address:



INTERNATIONAL HOUSE
12 CONSTANCE STREET
LONDON

E16 2DQ
ENGLAND

Standard Industrial Classification code:

62020 - Information technology consultancy activities


Company status:

Active

Company type:

Private Limited Company

Country of origin:

United Kingdom

Incorporated on:

23.03.2019

Type Of Accounts:


NO ACCOUNTS FILED

Accounts:


Last Accounts Made Up To 00.01.1900

Next Annual Accounts Due 23.12.2020

Confirmation statement:


Last Statement Dated 22.03.2020

Next Confirmation Statement Due 05.04.2021

Previous Company Name:

Companieshouse.gov.uk:


11900553

Description:

42 NEURONS LTD is a Private Limited Company incorporated on 23.03.2019 under the companies house number 11900553.

Website:

Phone Number:

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Additional resourses:

Harald Mosoarca - Lead Data Engineer and Director - 42 ...

    https://www.linkedin.com/in/harald-mosoarca-3686b1113

    Harald Mosoarca Lead Data Engineer and Director at 42 Neurons Ltd London, Greater London, United Kingdom 235 connections

Distinctive roles of different β-amyloid 42 aggregates in ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698658/

    Taken together, our data suggest that Aβ42 is secreted from neurons primarily as oligomers that inhibit neurotransmitter release and exert no effect on LTD . Whereas larger-sized aggregates, possibly fibrils, are major components secreted from muscle cells, which enhance synaptic transmission and LTD . Thus, different types of cells may secrete distinct forms of Aβ42 aggregates, leading to ...

miR-194 Accelerates Apoptosis of Aβ1–42-Transduced ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523401/

    Total RNA from normal hippocampal neurons (blank group) and hippocampal neurons induced by 30 μmol/L Aβ 1–42 (Aβ 1–42 group) were extracted by TRIzol reagent (Thermo Fisher Scientific, Waltham, MA, USA). A total of 0.5 mg RNA was subjected to the synthesis of cDNA by reverse transcription reaction. Fast Start Universal SYBR Green Mastermix (Roche, Basel, Switzerland) was selected to ...

Neuron loss in the 5XFAD mouse model of Alzheimer’s ...

    https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-8-2

    Quantitative analysis of large pyramidal neurons in Layer 5 of the cortex revealed a significant decrease in the number of neurons from 5XFAD mice at 9 and 12 months when compared to age matched non-transgenic littermate control mice (Figure 2A). At 6 months we observed a trend toward a decrease in neuron number within the 5XFAD group. Closer examination revealed two different 5XFAD mouse sub ...

Docosahexaenoic and eicosapentaenoic acids increase ...

    http://researchonline.rvc.ac.uk/id/eprint/1333/

    In untreated neurons, FITC-HuPrP82-146 migrated to caveolin-1 containing lipid rafts. The addition of HuPrP82-146 also triggered the migration of cytoplasmic phospholipase A(2) (cPLA(2)) into caveolin-1 containing rafts, and increased prostaglandin E-2 production. Activation of cPLA(2) and prostaglandin E-2 production were both increased in neurons pre-treated with DHA. These results are ...

Distinctive roles of different -amyloid 42 aggregates in ...

    https://www.researchgate.net/publication/24171619_Distinctive_roles_of_different_-amyloid_42_aggregates_in_modulation_of_synaptic_functions

    Taken together, our data suggest that Abeta42 is secreted from neurons primarily as oligomers that inhibit neurotransmitter release and exert no effect on LTD . Whereas larger-sized aggregates ...

Interferon-γ increases neuronal death in response to ...

    http://europepmc.org/articles/PMC1435873

    To determine if IFN-γ treated neurons show increased sensitivity to other neurotoxins, cortical neurons were treated with 100 pg/ml of IFN-γ prior to exposure to HuPrP82-146, a synthetic correlate of a neurotoxic peptide found in the brains of patients with prion disease , staurosporine or hydrogen peroxide. The survival of neurons pre-treated with IFN-γ was significantly less than that of ...

Interferon-γ increases neuronal death in response to ...

    https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-3-7

    Pre-treatment with IFN-γ reduces the survival of neurons incubated with amyloid-β 1-42.The survival of primary cortical neurons pre-treated with 1 ng/ml TNFα, IL-1β, IL-6 or IFN-γ prior to the addition of 10 μm amyloid-β 1-42 (shaded bars) or 10 μm amyloid-β 42-1 (open bars). Values shown are the mean percentage cell survival from triplicate experiments repeated 3 times (n = 9 ...

Neuron, Vol. 42, 225–236, April 22, 2004, Copyright 2004 ...

    https://core.ac.uk/download/pdf/81203346.pdf

    neurons that, unlike previously described forms of en-nalization of growth factor receptors (Vieira et al., 1996), ... we show that mem-( LTD ) of synaptic efficacy in the hippocampus and cere-brane depolarization induces RE in the absence of bellum (Man et al., 2000; Wang and Linden, 2000). In all calcium. Inhibition of dynamin function does not af- these cases, dynamin functions at a key step ...

Aggregated Aβ1-42 Is Selectively Toxic for Neurons ...

    https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(18)30108-9

    Drosophila has become a widely used model system to study neurodegenerative disorders, among them AD. Amyloid plaques in human AD consist of different variants of the Aβ peptide, with the most abundant being Aβ1-40 and Aβ1-42. It has been shown that expression of Aβ1-42 in neurons of the fly CNS is toxic and cause shortened lifespan, progressive protein accumulation, impaired locomotor ...

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